Trang: 59
Tập 34, số 8 2024
Epidemiology of acute diarrhea caused by rotavirus in sentinel surveillance sites of Vietnam, 2016-2023
Tác giả: Dang Thi Thanh Huyen, Phan Trong Lan, Nguyen Thanh Trung, Cu Ngoc Tung Lam, Tran
Trung Thanh, An Hong Lien, Tran Thi Nguyen Hoa, Vu Manh Hung, Duong Thi Hong
Tóm tắt:
This study was conducted in four sentinel surveillance hospitals to describe the epidemiology of acute diarrhea caused
by rotavirus and the molecular epidemiology among children under 5 years old in Vietnam. From 2016 to2023, a total
of 14,647 stool specimens were collected for testing. 4,893 cases (33.4%) tested positive for rotavirus, in which 2,660
positive specimens were tested for genotype. The positive rate decreased gradually from 46.6% (2016) to 17.3% (2023).
Although rotavirus was detected year-round, peak incidence occurred during the period from October to March. Positivity rates varied by age, highest in children aged 12–23 months (41.3%) and 24–59 months (36.5%). Rotavirus-positive children experienced an average of 7.8 episodes (95% CI: 7.7–7.9) diarrhea episodes within 24 hours and a higher
rate of severe dehydration (4.7%) than rotavirus-negative children (7.4 episodes, 95% CI: 7.3–7.5; and 3.1%). Rotavirus infection and severe dehydration rates in the unvaccinated group were 35.2% and 5.1% higher than those in
the vaccinated group (20.9% and 0.5%). The genotyping data revealed changes in variation of genotype distribution
and in prevalent genotypes circulating over time: the co-dominance of variety of prevalent genotypes G1P[8], G2P[4],
G3P[8], G8P[8], G9P[8] (2016–2021) was replaced by the predominance of G3P[8] (98%) (2022–2023). In conclusion, rotavirus infection remains a leading cause of acute diarrhea and severe dehydration among hospitalized children
in Vietnam. Infection rate and variation in the genotype distribution of rotavirus tended to decrease. The introduction
of the rotavirus vaccine into EPI could significantly reduce the burden of this disease.
Summary:
Từ khóa:
Acute diarrhea; Rotavirus; children under 5 years old; Vietnam; epidemiology; immunization; genotype; sentinel surveillance
DOI: https://doi.org/10.51403/0868-2836/2024/2144
File nội dung:
bai-6.pdf
Tải file:
