Trang: 7
Tập 33, số 8 2023
Evaluation of IgG antibody response to diphtheria toxin one month after tetanus-diphtheria vaccination among 7-years-old children in a mountainous district in the Northern region of Viet Nam in 2020
Tác giả: Tran Thi Lan Anh, Duong Thi Hong, Dang Thi Thanh Huyen, Nguyen Thanh Trung, Nguyen Trung
Thanh, Nguyen Cong Luat, Trieu Thi Thanh Van, Pham Quang Thai, Hoang Thi Thu Ha
Tóm tắt:
Under the outbreak of diphtheria disease mostly among preschool and primary school children, following the
recommendations of WHO, Vietnam has implemented a second booster dose of diphtheria vaccine since 2019 for children
at 7 years old in some at-risk provinces. This study evaluated the IgG antibody response to diphtheria toxid in a group
of 7-year-old children living in Tran Yen district, Yen Bai province, after receiving one dose of Tetanus-diphtheria (Td)
vaccine with reduced diphtheria toxoid in 2020. The study involved community intervention, monitoring 98 7-yearold children who received the Td vaccine to compare the proportion of children with a full protective antibody level
(antibody concentration ≥ 0.1IU/mL) before and one month after vaccination. The results showed that the proportion
of children with a protective antibody level against diphtheria toxin increased from 35% to 95% one month after
vaccination. The intervention coefficient was 171%. 80% of children achieved long-term protective antibody levels (≥
1.0IU/mL). The Td vaccine helped children achieve full and long-term protective antibody levels, even in those without
the complete primary vaccination series and those with only baseline or no protection levels. Vaccinating 7-year-old
children in areas with limited vaccination coverage and no actual circulating diphtheria cases is effective and necessary
to prevent disease outbreaks. The study’s results suggest the Ministry of Health should consider including the Td
vaccine in the Expanded Immunization Program for regular vaccination for 7-year-old children instead of approving
current annual plans.
Summary:
Từ khóa:
Antibodies against diphtheria; tetanus-reduced diphtheria-tetanus vaccine; Td, 7-year-old child; Northern mountainous region
DOI: https://doi.org/10.51403/0868-2836/2023/1472
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o230807.pdf
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